This tutorial will provide practical information and advice to enable experienced OpenMP and MPI programmers to enhance applications on the manycore architectures. We’ll discuss the impact on performance of MCDRAM memory on the Xeon Phi processor and provide recommendations regarding MPI and OpenMP task layout. We also will showcase Intel VTune Amplifier XE’s and dvisor’s capabilities to provide detailed memory analysis and parallel code profiling. Optimization methods in multithreading will be covered in depth.